Pep Guardiola’s team may have been missing six first-team players. But they will remain big favourites to get the win they need to retain their title.
Manchester United go into the game on the back of two successive away draws, against Bournemouth and St Etienne, before falling at Chelsea on Sunday.
Liverpool have only lost twice at Old Trafford this season – to United in December, and at home to West Ham in the League Cup semi-final at the end of January.
The Red Devils’ approach, with so many absentees, has been criticised by former United goalkeeper Edwin van der Sar, but there will be confidence among his compatriots that they will maintain the momentum.
BBC Sport will bring you all the action live from Old Trafford, with all the analysis, goals and reaction.
You can also keep up with the build-up, and how the build-up will play out on the live text commentary box for the whole of the game.
Kick-off: Friday, 27 February at 19:45 GMT
Venue: Old Trafford, Manchester
BBC Radio 5 live: Radio 5 live will have full live commentary on 5 live sports extra. Nick Harris and Jeff Stelling will commentate for BBC Radio 5 live.
Full team news
Manchester United: Given, Darmian, Daley Blind, Valencia, Smalling, Shaw, Fellaini, Matic, Lingard, Martial, Lukaku.
Liverpool: Mignolet, Alexander-Arnold, Lovren, Matip, Milner, Wijnaldum, Henderson, Keita, Firmino, Salah, Sturridge.
You can follow live text commentary of all of Liverpool’s matches, and highlights of the big games on BBC Sport’s Premier League.
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View from a fan
Bergy Jonsdottir, @BergyJonsdottir, @Berty4ger.
‘It’s really important’
Former Manchester United striker Alan Smith: “Manchester United are in second – six points behind leaders Manchester City.
“So, they’ve got to win this match. Liverpool could drop more points in the next few games.
“They are (fighting for the title) but Liverpool have got a game in hand. Manchester United don’t and this is a massive game for them.”